Synlett

Synthetic approach to tetrodotoxin

T Itoh, M Watanabe, T Fukuyama

Index: Itoh, Tetsuji; Watanabe, Manabu; Fukuyama, Tohru Synlett, 2002 , # 8 p. 1323 - 1325

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Citation Number: 21

Abstract

Abstract A novel and stereoselective approach to tetrodotoxin is described. The tricyclic compound having several key functional groups on the cyclohexane ring was synthesized from p-anisaldehyde with control of the four chiral centers. Iodoaminocyclization, 1, 3-dipolar cycloaddition, and Baeyer-Villiger oxidation are the key steps of our approach.

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