(−)-Carbodine: Enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 ( …

JR Rao, AK Jha, RK Rawal, A Sharon, CW Day…

Index: Rao, Jagadeeshwar R.; Jha, Ashok K.; Rawal, Ravindra K.; Sharon, Ashoke; Day, Craig W.; Barnard, Dale L.; Smee, Donald F.; Chu, Chung K. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 8 p. 2601 - 2604

Full Text: HTML

Citation Number: 11

Abstract

Enantiomerically pure cyclopentyl cytosine [(−)-carbodine 1] was synthesized from d-ribose and evaluated for its anti-influenza activity in vitro in comparison to the (+)-carbodine,(±)- carbodine and ribavirin.(−)-Carbodine 1 exhibited potent antiviral activity against various strains of influenza A and B viruses.

Related Articles:

Synthesis and incorporation of carbocyclic nucleosides into a hammerhead ribozyme domain–RNase resistance and catalytic activity

[Burlina, Fabienne; Favre, Alain; Fourrey, Jean-Louis; Thomas, Martial Chemical Communications, 1996 , # 14 p. 1623 - 1624]

An expeditious route to carbocyclic nucleosides:(−)-aristeromycin and (−)-carbodine

[Burlina, Fabienne; Favre, Alain; Fourrey, Jean-Louis; Thomas, Martial Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 3 p. 247 - 250]

An expeditious route to carbocyclic nucleosides:(−)-aristeromycin and (−)-carbodine

[Burlina, Fabienne; Favre, Alain; Fourrey, Jean-Louis; Thomas, Martial Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 3 p. 247 - 250]

An expeditious route to carbocyclic nucleosides:(−)-aristeromycin and (−)-carbodine

[Burlina, Fabienne; Favre, Alain; Fourrey, Jean-Louis; Thomas, Martial Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 3 p. 247 - 250]

An expeditious route to carbocyclic nucleosides:(−)-aristeromycin and (−)-carbodine

[Burlina, Fabienne; Favre, Alain; Fourrey, Jean-Louis; Thomas, Martial Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 3 p. 247 - 250]

More Articles...