Organic sulfur compounds. VII. Some reactions of benzothiazine hydroxamic acids

RT Coutts, SJ Matthias, E Mah…

Index: Coutts,R.T. et al. Canadian Journal of Chemistry, 1970 , vol. 48, p. 3727 - 3732

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Citation Number: 3

Abstract

Treatment of (3, 4-dihydro-4-hydroxy-3-oxo-2 H-1, 4-benzothiazin-2-yl) acetic acid (1 a) with sodium hydroxide yields the corresponding lactam, ie(3, 4-dihydro-3-oxo-2 H-1, 4- benzothiazin-2-yl) acetic acid, together with the α, β-unsaturated acid, 3, 4-dihydro-3-oxo-2 H-1, 4-benzothiazine-Δ2, α-acetic acid. The 6-methyl-and 6-bromo-derivatives of 1 a behaved similarly when reacted with sodium hydroxide but when 3, 4-dihydro-4-hydroxy-3 ...