A Two??Step Continuous??Flow Synthesis of N??(2??Aminoethyl) acylamides through Ring??Opening/Hydrogenation of Oxazolines

B Gutmann, JP Roduit, D Roberge…

Index: Gutmann, Bernhard; Roduit, Jean-Paul; Roberge, Dominique; Kappe, C. Oliver Chemistry - A European Journal, 2011 , vol. 17, # 47 p. 13146 - 13150

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Citation Number: 16

Abstract

2-Oxazolines are a readily available class of heterocycles that are easily generated from aminoalcohols and carboxylic acids, or through alternative synthetic procedures starting from alkenes or epoxides as substrates.[1, 2] The oxazoline moiety is very resistant against a range of reagents, such as nucleophiles, bases, or radicals, and is, therefore, heavily used as protecting and/or directing group, or as a powerful source of chirality in asymmetric ...