Synthetic Communications

A preparative synthesis of D, l-gabaculine

JP François, MW Gittos

Index: Francois,J.-P.; Gittos,M.W. Synthetic Communications, 1979 , vol. 9, p. 741 - 750

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Citation Number: 17

Abstract

Abstract The γ-aminobutyric acid-α-ketoglutaric acid transaminase inhibitor, gabaculine (1) was first isolated as an optically active amorphous powder from a culture filtrate of streptomyces toyacaenis subspecies 1039 by Mishima and co-workers in 19761. The structure (1) was assigned on the basis of physical and chemical data and has been confirmed by two total syntheses of the racemic compound1, 2.