A convenient synthesis of p-substituted 1-arylsulfonyl-pyrrolidin-2-ones

…, KM Khan, JH Zaidi, Zia-Ullah, M Arfan

Index: Zareef, Muhammad; Iqbal, Rashid; Khan, Khalid M.; Zaidi, Javid H.; Zia-Ullah; Arfan, Muhammad Natural Product Research, 2009 , vol. 23, # 5 p. 485 - 488

Full Text: HTML

Citation Number: 2

Abstract

A convenient and novel method of cyclisation of 4-(4-substituted-phenylsulfonamido)- butanoic acids to their corresponding p-substituted 1-arylsulfonyl-pyrrolidin-2-ones was achieved by using polyphosphate ester (PPE). The reaction times were considerably reduced, with an increase in yields, when PPE was used in combination with a catalytic amount of pyridine.