Novel biodegradable pyridinium amphiphiles for gene delivery

…, J Šmisterová, A Wagenaar, D Hoekstra…

Index: Pijper, Dirk; Bulten, Erna; Smisterova, Jarmila; Wagenaar, Anno; Hoekstra, Dick; Engberts, Jan B. F. N.; Hulst, Ron European Journal of Organic Chemistry, 2003 , # 22 p. 4406 - 4412

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Citation Number: 22

Abstract

Abstract Biodegradable synthetic cationic pyridinium-based amphiphiles (SAINTs) prove to be promising non-viral carrier systems for delivery of DNA into eukaryotic cells. Six novel SAINTs were synthesised from 3, 5-pyridinedicarboxylic acid as starting material, with two ester groups as linkers between the cationic headgroup and the hydrophobic tails. The vesicle-forming properties of the amphiphiles were studied by differential scanning ...