An efficient and facile one-pot synthesis of cyanohydrin esters from carbonyl compounds catalyzed by iron (III) chloride

K Iwanami, M Aoyagi, T Oriyama

Index: Iwanami, Katsuyuki; Aoyagi, Masaru; Oriyama, Takeshi Tetrahedron Letters, 2005 , vol. 46, # 44 p. 7487 - 7490

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Citation Number: 26

Abstract

O-Protected cyanohydrin derivatives constitute versatile intermediates in organic synthesis, 1 and several direct methods for their preparation have been reported so far. Cyanohydrin silyl ethers are prepared from carbonyl compounds with trialkylsilyl cyanide under the influence of Lewis acids, 2 Lewis bases, 3 or organocatalyst. 4 For cyanohydrin alkyl ethers, we recently demonstrated a convenient one-pot synthesis directly from aldehydes with trimethylsilyl ...