Synthesis and biological activity of N-(1-R-2, 2, 2-trichloroethyl) benzfnfsulfonamides

…, ÉÉ Kuznetsova, GS Vavil'chenkova…

Index: Mirskova, A. N.; Drozdova, T. I.; Levkovskaya, G. G.; Kuznetsova, E. E.; Vavil'chenkova, G. S.; et al. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 12 p. 899 - 902 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 12 p. 1479 - 1481

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Abstract

In the first step of the reaction, trichloroethylidine benzenesulfonamide Vll-i (5) is formed by addition of the amide (VI) to (VII). Subsequent addition of another molecule of VI gives (IX). A chlorine atom of the intermediate (IX) exchanges for hydrogen with extraordinary ease in the presence of moisture to give the desired product I.