Synthesis of 1, 2-benzisoxazole 2-oxides

MG Kociolek, O Hoermann

Index: Kociolek, Martin G.; Hoermann, Olivia Synthetic Communications, 2012 , vol. 42, # 17 p. 2632 - 2638

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Citation Number: 4

Abstract

With this in mind, a number of hypervalent iodine compounds were investigated for the cyclization of 2-hydroxyaryl ketoximes. Initially, the cyclization was attempted with Koser's reagent (HTIB) and 1H-1-hydroxy-5-methyl-1,2,3-benziodoxathiole 3,3-dioxide (HMBI) under a variety of conditions with neither reagent giving any cyclized products. However, treatment of the oximes with iodobenzene diacetate yielded 1,2-benzisoxazole 2-oxides as the major products. It ...