… external and internal electrophiles in reactions of functionalized organolithium reagents. A new route to isoindoline derivatives and 1, 2, 3, 4-tetrahydroisoquinolines

CK Bradsher, DA Hunt

Index: Bradsher, Charles K.; Hunt, David A. Journal of Organic Chemistry, 1981 , vol. 46, # 2 p. 327 - 330

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Citation Number: 18

Abstract

4 anion. R e~ ently~?~ it was shown that 3, 4-dihydroisoquinolines could be prepared by the indirect method, through the addition of suitable nitriles to o-(Zbromoethy1) phenyllithium. One purpose of the present work was to investigate the possibility of forming dihydroisoindole derivatives by the indirect method using Schiff bases as the added electrophile.