Analgetic-antiinflammatory activity of prenyl derivatives of basic naphthylalkylnitriles and naphthylalkylamides chemically related to naphthypramide

G Pala, A Donetti, B Lumachi…

Index: Pala,G. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, # 6 p. 720 - 723

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Abstract

In marked contrast, in the S series progressive alkyl substitution causes an initial decrease in pDp value with DMD and this is approximately equal in both the R and S series. Additional alkyl substitution produces no further change in pD2 but rather causes a progressive decrease in ia (Figure