Studies on the photostability and in vitro phototoxicity of Labetalol

V Andrisano, R Ballardini, P Hrelia, N Cameli…

Index: Andrisano, Vincenza; Ballardini, Roberto; Hrelia, Patrizia; Cameli, Norma; Tosti, Antonella; Gotti, Roberto; Cavrini, Vanni European Journal of Pharmaceutical Sciences, 2001 , vol. 12, # 4 p. 495 - 504

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Citation Number: 36

Abstract

The purpose of this study was to obtain information on the photochemical and phototoxic properties of Labetalol, a beta-blocker drug. Preliminary information on the drug photoreactivity was achieved using a flow system with a photochemical reactor on-line with a diode array detection system. Photophysical and photochemical investigations on the drug were performed in aqueous solutions at different pH values using spectrophotometric and ...