The preparation of two, preclinical amino-quinazolinediones as antibacterial agents

V Beylin, DC Boyles, TT Curran…

Index: Organic Process Research and Development, , vol. 11, # 3 p. 441 - 449

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Citation Number: 18

Abstract

... Process Res. ... A commercially available and relatively inexpensive electrophilic amination was tried using H 2 NOSO 3 H (Scheme 6). This procedure provided very ... Of the organic bases screened, TMG (2.8 equiv) again proved to be the best base, and it was important to use side ...