Syntheses of 2-Amino-3, 4-dimethyl-3H-imidazo [4, 5-f] quinoline and Its Related Compounds

H Kasai, S Nishimura

Index: Kasai, Hiroshi; Nishimura, Susumu Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 7 p. 2233 - 2235

Full Text: HTML

Citation Number: 16

Abstract

The strongly mutagenic compound, 2-amino-3, 4-dimethyl-3H-imidazo [4, 5-f] quinoline (Me- IQ), isolated from broiled sardines was synthesized from 6-amino-7-methylquinoline. Several structurally related compounds were also synthesized to clarify the structure-activity relationship. Some of them also showed strong mutagenic activity towards Salmonella typhimurium TA98.