Construction of Enantioenriched Cyclic Compounds by Asymmetric Allylic Alkylation and Ring??Closing Metathesis

F Giacomina, A Alexakis

Index: Giacomina, Francesca; Alexakis, Alexandre European Journal of Organic Chemistry, 2013 , # 29 p. 6710 - 6721

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Citation Number: 4

Abstract

Abstract A new approach to highly enantioenriched cyclic compounds (up to 98% ee) has been developed by using ω-ethylenic allylic substrates in a one-pot asymmetric allylic alkylation and ring-closing metathesis sequence. The starting compounds are synthetic equivalents of cyclic allylic substrates. The method is exemplified with both Cu and Ir catalysts, and chiral phosphoramidite ligands.