3-Hydroxy-quinazoline-2, 4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists

…, F Varano, FR Calabri, G Filacchioni, C Costagli…

Index: Colotta, Vittoria; Catarzi, Daniela; Varano, Flavia; Calabri, Francesca Romana; Filacchioni, Guido; Costagli, Chiara; Galli, Alessandro Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2345 - 2349

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Citation Number: 34

Abstract

The synthesis and Gly/NMDA, AMPA and KA receptor binding activities of some 3-hydroxy- quinazoline-2, 4-dione derivatives are reported. The binding data, together with functional antagonism studies, showed that the 3-hydroxy-quinazoline-2, 4-dione moiety can be considered a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists. In fact, introduction of chlorine atom (s) on precise position (s) of the benzofused moiety ...