Cardiotonic agents. 1-Methyl-7-(4-pyridyl)-5, 6, 7, 8-tetrahydro-3 (2H)-isoquinolinones and related compounds. Synthesis and activity

…, K Sannohe, S Kajiya, T Suzuki, K Otsuka…

Index: Kaiho, Tatsuo; San-nohe, Kunio; Kajiya, Seitaro; Suzuki, Tsuneji; Otsuka, Kengo; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 351 - 357

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Citation Number: 30

Abstract

P as described in the Experimental Section. ED,, values were determined by log dose. The data are summarized in Tables I and 11. The substituents at the 1-, 4-, and 7-positions on isoquinolinone were systematically modified to optimize the inotropic activity. Considerable loss of activity was observed by manipulation of the lactam moiety in this series of compounds (12, E), indicating that a tautomerizable acidic proton is required for significant ...