7-Substituted 5-amino-2-(2-furyl) pyrazolo [4, 3-e]-1, 2, 4-triazolo [1, 5-c] pyrimidines as A2A adenosine receptor antagonists: a study on the importance of …

…, R Romagnoli, G Spalluto, A Monopoli…

Index: Baraldi; Cacciari; Romagnoli; Spalluto; Monopoli; Ongini; Varani; Borea Journal of Medicinal Chemistry, 2002 , vol. 45, # 1 p. 115 - 126

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Citation Number: 103

Abstract

It was demonstrated in the early 1990s that adenosine exerts many physiological functions through the interaction with four different receptors, named A1, A2A, A2B, and A3. In the past few years, our group has been involved in the development of A2A antagonists, which led to the synthesis of SCH 58261 (1), the first potent and selective adenosine A2A antagonist, which has been widely used as a reference compound. In this paper, we present an ...

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