Palladium??Catalyzed Direct C–H Arylation of Thieno [3, 4??b] pyrazines: Synthesis of Advanced Oligomeric and Polymeric Materials

…, AA El??Shehawy, AA El??Barbary…

Index: Abdo, Nabiha I.; El-Shehawy, Ashraf A.; El-Barbary, Ahmed A.; Lee, Jae-Suk European Journal of Organic Chemistry, 2012 , # 28 p. 5540 - 5551

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Citation Number: 31

Abstract

Abstract The first examples are reported of an efficient regioselective direct C–H arylation of thieno [3, 4-b] pyrazine (TP) and its 2, 3-dimethyl derivative with bromoalkylthiophenes (BATs), under Heck experimental conditions using Pd (OAc) 2/Bu 4 NBr as the catalytic system, giving rise to a variety of valuable aryl-substituted thienopyrazines. The obtained results suggested that the 2-position of the TP moiety is less reactive towards C–H ...