Mercury (II)??Catalyzed Cyclization of 2??Alkynylphenyl Alkyl Sulfoxides Provides 3??Acylbenzo [b] thiophenes

CH Lin, CC Chen, MJ Wu

Index: Lin, Cheng-Han; Chen, Chin-Chau; Wu, Ming-Jung Chemistry - A European Journal, 2013 , vol. 19, # 8 p. 2578 - 2581

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Citation Number: 4

Abstract

Molecules that contain the benzo [b] thiophene substructure often exhibit a broad spectrum of biological activities.[1] For instance, raloxifene (1) and compound 2 have been reported as unique selective estrogen receptor modulators (SERMs) and antitubulin agents.[2] Recently, raloxifene was found to be as effective as tamoxifen in reducing the risk of invasive breast cancer and has lower risk of thromboembolic events and cataracts.[3] Therefore, ...