Synthesis and biological evaluation of indazolo [4, 3-bc][1, 5] naphthyridines (10-aza-pyrazolo [3, 4, 5-kl] acridines): a new class of antitumor agents

…, R Lucciarini, M Michela, C Amantini, G Santoni…

Index: Magnano, Amelia; Sparapani, Silvia; Lucciarini, Roberta; Michela, Mosca; Amantini, Consuelo; Santoni, Giorgio; Antonini, Ippolito Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 22 p. 5941 - 5947

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Citation Number: 10

Abstract

A series of potential DNA-binding antitumor agents, 2-[ω-(alkylamino) alkyl]-9-methoxy-5- nitro-2, 6-dihydroindazolo [4, 3-bc][1, 5] naphthyridines (2a–f), 10-aza derivatives of PZA, has been prepared by condensation of 9-chloro-2-methoxy-6-nitro-5, 10-dihydrobenzo [b][1, 5] naphthyridin-10-one (6) with the appropriate (ω-aminoalkyl) hydrazine in tetrahydrofuran/ methanol. Compound 6 was obtained by heating at 100° C in H2SO45, yielded by the ...