Reactions of secondary propargylamines with heteroallenes for the synthesis of diverse heterocycles

Vsevolod A. Peshkov, Olga P. Pereshivko, Anton A. Nechaev, Anatoly A. Peshkov, Erik V. Van der Eycken

Index: 10.1039/C7CS00065K

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Abstract

This focused review aims to summarize recent developments in the processes involving additions of secondary propargylamines to various heteroallenes and subsequent transition metal-catalyzed or electrophile-mediated cyclizations. The utility of this convenient and tunable strategy spans from the carbon dioxide fixation and target-oriented synthesis of complex natural and biologically active products to the generation of extended synthetic libraries of diverse oxygen-, nitrogen- and sulfur-containing heterocycles. For comparative purposes, the analogous transformations of propargylic alcohols are also highlighted in this account.