Convenient preparation of polyfunctional aryl magnesium reagents by a direct magnesium insertion in the presence of LiCl

…, P Appukkuttan, A Gavryushin, M Helm…

Index: Piller, Fabian M.; Appukkuttan, Prasad; Gavryushin, Andrei; Helm, Matthew; Knochel, Paul Angewandte Chemie - International Edition, 2008 , vol. 47, # 36 p. 6802 - 6806

Full Text: HTML

Citation Number: 177

Abstract

The preparation of complex polyfunctional organometallic reagents is of pivotal interest in organic synthesis.[1] Recently, functionalized organomagnesium reagents have become accessible through a halogen/magnesium exchange [2] or a directed metalation.[3] During these studies it became apparent that aryl magnesium halides are compatible with important functional groups, such as cyano, nitro, ester, or even keto groups.[4] This observation ...

Related Articles:

Synthesis, characterization and X-ray structures of N-heterocyclic carbene palladium complexes based on calix [4] arenes: highly efficient catalysts towards Suzuki– …

[Ren, Hui; Xu, Yong; Jeanneau, Erwann; Bonnamour, Isabelle; Tu, Tao; Darbost, Ulrich Tetrahedron, 2014 , vol. 70, # 17 p. 2829 - 2837]

Radical Catalysis of Kumada Cross??Coupling Reactions Using Functionalized Grignard Reagents

[Manolikakes, Georg; Knochel, Paul Angewandte Chemie - International Edition, 2009 , vol. 48, # 1 p. 205 - 209]

Microwave-assisted Negishi and Kumada cross-coupling reactions of aryl chlorides

[Walla, Peter; Kappe, C. Oliver Chemical Communications, 2004 , # 5 p. 564 - 565]

Manganese-catalyzed substitution of activated aryl halides (X= Cl, Br and F) and aryl ethers by organomagnesium reagents

[Cahiez, Gerard; Lepifre, Franck; Ramiandrasoa, Parfait Synthesis, 1999 , # 12 p. 2138 - 2144]

A Highly Practical and Reliable Nickel Catalyst for Suzuki–Miyaura Coupling of Aryl Halides

[Zhao, Yu-Long; Li, You; Li, Shui-Ming; Zhou, Yi-Guo; Sun, Feng-Yi; Gao, Lian-Xun; Han, Fu-She Advanced Synthesis and Catalysis, 2011 , vol. 353, # 9 p. 1543 - 1550]

More Articles...