[1, 4] Benzoxazine-2, 3-diones as antiallergic agents
B Loev, H Jones, RE Brown, FC Huang…
Index: Loev, Bernard; Jones, Howard; Brown, Richard E.; Huang, Fu-chih; Khandawala, Atul; et. al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 24 - 27
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Citation Number: 15
Abstract
Incubations were conducted in the same manner as in the kinetic studies except each flask contained 10 mM of a low-molecularweight nucleophile (L-methionine, L-cysteine, glutathione, guanosine phosphate) or 1 mg/mL of tRNA. A saturating concentration of inactivator (N-arylhydroxamic acid) was used and preincubation times (2-20 min) were adjusted such that maximum inactivation of the enzyme occurred. Control flasks contained ...
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