Silicon-directed Nazarov cyclization

SE Denmark, TK Jones

Index: Denmark, S. E.; Jones, T. K. Journal of the American Chemical Society, 1982 , vol. 104, # 9 p. 2642 - 2645

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Citation Number: 116

Abstract

Sa-g 6a-g chemistry in synthesi~.~~.~ We reasoned that strategic placement of a trimethylsilyl group as shown in Scheme I1 could direct the introduction of the new double bond in a Nazarov cyclization to the less substituted position, Le., away from the ring fusion. a The obvious advantages of such an outcome are (1) controlled introduction of potential functionality based on the double bond and (2) ready isomerization of the double bond ...

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