Tetrahedron Letters

Addition of boron enolates to isoquinolinium salts: A facile synthesis of 1-β-keto substituted 2-ethoxycarbonyl-1, 2-dihydroisoquinolines and their cyclization

K Akiba, K Araki, M Nakatani, M Wada

Index: Akiba, Kin-ya; Araki, Kei-ichi; Nakatani, Masayuki; Wada, Makoto Tetrahedron Letters, 1981 , vol. 22, # 49 p. 4961 - 4964

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Citation Number: 13

Abstract

Abstract An efficient method to synthesize 1-β-keto substituted 2-ethoxycarbonyl (or 2-acetyl)- 1, 2-dihydroisoquinolines (3) is described, utilizing boron enolates and isoquinolinium salts. The products were treated with sodium ethoxide to afford the corresponding cyclic compounds (6).