Ruthenium??Catalyzed Reductive Coupling of 1, 3??Enynes and Aldehydes by Transfer Hydrogenation: anti??Diastereoselective Carbonyl Propargylation

LM Geary, JC Leung, MJ Krische

Index: Geary, Laina M.; Leung, Joyce C.; Krische, Michael J. Chemistry - A European Journal, 2012 , vol. 18, # 52 p. 16823 - 16827

Full Text: HTML

Citation Number: 9

Abstract

Abstract Under the conditions of ruthenium-catalyzed transfer hydrogenation employing isopropanol as a source of hydrogen, isopropoxy-substituted enyne 1 b and aldehydes 3 a– 3 l engage in reductive coupling to provide products of propargylation 4 a–4 l with good to complete levels of anti-diastereoselectivity. The unprotected tertiary hydroxy moiety of isopropoxy enyne 1 b is required to enforce diastereoselectivity. Deuterium-labeling ...