Synthesis and antiviral activity of novel N-substituted derivatives of acyclovir

…, B Golankiewicz, E De Clercq

Index: Boryski, Jerzy; Golankiewicz, Bozenna; Clercq, Erik De Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1351 - 1355

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Citation Number: 69

Abstract

Novel N-substituted derivatives of acyclovir (la) were synthesized and evaluated for their antiviral, antimetabolic, and antitumor cell properties in vitro. Monomethylation of la at positions 1, 7, and N-2 gave compounds 2-4, respectively. When positions 1 and N-2 were linked together by an isopropeno group, the tricyclic 9-[(2-hydroxyethoxy) methyl]-1, N-2- isopropenoguanine (5) was obtained. Compound 5 was then further methylated at ...