Synthesis of iodine-125 labeled (.+-.)-15-[4-azidobenzyl] carazolol: a potent. beta.-adrenergic photoaffinity probe

SL Heald, PW Jeffs, TN Lavin, P Nambi…

Index: Heald; Jeffs; Lavin; Nambi; Lefkowitz; Caron Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 832 - 838

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Citation Number: 21

Abstract

(~)-15-(4-Azidobenzyl) carazolol (2), a potent@-adrenergic photoaffinity ligand developed in our laboratories, has been radioiodinated to theoretical specific activity (2175 Cifmmol) and shown to label covalently@-adrenergic receptor peptides in avian and amphibian erythrocyte membrane preparations. The radioiodinated analogues of the desired compound (2) were optimally prepared by two synthetic steps from (A)-15-(4-aminobenzyl ...