Synthesis and biological activity of trans-(.+-.)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (RP 49356) and analogs: a new class of potassium …

TJ Brown, RF Chapman, DC Cook…

Index: Brown, Thomas J.; Chapman, Robert F.; Cook, David C.; Hart, Terance W.; McLay, Iain M.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3613 - 3624

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Citation Number: 46

Abstract

The synthesis and biological activity of trans-(f)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyr- ancarbothioamide 1-oxide@ a, RP 49356) and analogues is reported. These compounds constitute a new structural class of K+-channel opener. The effects of changes in the pyridyl group, thioamide, and thiane ring on in vitro K+-channel opening activity are discussed. A 3- pyridyl or 3-quinolyl group, a small N-alkyl thioamide function, and a thiane oxide ring, in ...