Novel 1, 2, 3-triazole derivatives for use against Mycobacterium tuberculosis H37Rv (ATCC 27294) strain

…, MM Bastos, MS Costa, MCS Lourenço…

Index: Boechat, Nubia; Ferreira, Vitor F.; Ferreira, Sabrina B.; Ferreira, Maria De Lourdes G.; Da Silva, Fernando De C.; Bastos, Monica M.; Costa, Marilia Dos S.; Lourenco, Maria Cristina S.; Pinto, Angelo C.; Krettli, Antoniana U.; Aguiar, Anna Caroline; Teixeira, Brunno M.; Da Silva, Nathalia V.; Martins, Priscila R. C.; Bezerra, Flavio Augusto F. M.; Camilo, Ane Louise S.; Da Silva, Gerson P.; Costa, Carolina C. P. Journal of Medicinal Chemistry, 2011 , vol. 54, # 17 p. 5988 - 5999

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Citation Number: 94

Abstract

The purpose of this study was to prepare various 4-substituted N-phenyl-1, 2, 3-triazole derivatives using click chemistry. The derivatives were screened in vitro for antimicrobial activity against Mycobacterium tuberculosis strain H37Rv (ATCC 27294) using the Alamar Blue susceptibility test. The activity was expressed as the minimum inhibitory concentration (MIC) in μg/mL (μM). Derivatives of isoniazid (INH),(E)-N′-[(1-aryl)-1 H-1, 2, 3-triazole-4- ...