Asian Journal of Chemistry

Synthesis and Antiinflammatory Properties of N-Substituted Guanidines

S Pathak, D Singh, VP Singh

Index: Pathak, Santosh; Singh, Dhananjay; Singh, Ved Prakash Asian Journal of Chemistry, 2011 , vol. 23, # 6 p. 2483 - 2486

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Abstract

Abstract Various N [(p-substituted/unsubstituted) phenyl),(substituted thiazol-2-yl/oxazol-2- yl/naphthothiazol-2-yl)], N'-[N"', N"'-dimethyl/diethylaminoacetyl], N"-phenyl guanidines were prepared from corresponding N-substituted thiocarbamides and were evaluated for their antiinflammatory activity. All the substituted guanidines (100 mg/Kg) provided 1-79% protection against carrageenin induced edema in rats. Phenyl butazone (100 mg/Kg) was ...