Tetrahedron letters

Synthesis of 8-arylsulfoxyl/sulfonyl adenines

L Llauger, H He, G Chiosis

Index: Llauger, Laura; He, Huazhong; Chiosis, Gabriela Tetrahedron Letters, 2004 , vol. 45, # 52 p. 9549 - 9552

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Citation Number: 10

Abstract

We report a method for the synthesis of 9-N-alkyl-8-arylsulfoxyl adenines and 9-N-alkyl-8- arylsulfonyl adenines. The approach starts with a tandem one-pot reaction that by using Mitsunobu conditions converts 8-arylsulfanyl adenines to the corresponding iminophosphorane protected 9-N-alkyl-8-arylsulfanyl adenines. These compounds were further subjected to selective OXONE®/alumina mediated oxidation followed by ...