A general and mild copper-catalyzed three-component synthesis of protected homoallyl amines

KK Pasunooti, ML Leow, S Vedachalam, BK Gorityala…

Index: Pasunooti, Kalyan Kumar; Leow, Min Li; Vedachalam, Seenuvasan; Gorityala, Bala Kishan; Liu, Xue-Wei Tetrahedron Letters, 2009 , vol. 50, # 24 p. 2979 - 2981

Full Text: HTML

Citation Number: 19

Abstract

A mild and highly efficient copper-catalyzed, one-pot, three-component reaction is developed for the synthesis of homoallyl amines. Reaction of an aldehyde, a carbamate, and allyltrimethylsilane in the presence of 5mol% Cu (OTf) 2 furnishes the corresponding protected homoallylic amines in good to excellent yields.