A catalytic asymmetric synthesis of a versatile intermediate for phorbol derivatives

H Sato, YS Kim, M Shibasaki

Index: Sato, Hideaki; Kim, Yun Sik; Shibasaki, Masakatsu Tetrahedron Letters, 1999 , vol. 40, # 15 p. 2973 - 2976

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Citation Number: 16

Abstract

A catalytic asymmetric cyclopropanation of enol silyl ether 9 gave the lactone 3 in up to 78% ee. The lactone 3 was then transformed into 2, potentially a very versatile intermediate for phorbol analogs, using an intramolecular nitrile oxide cycloaddition as a key step. ... Compound 13 was obtained as a mixture (trans:cis=1:1). ... The stereochemistry was determined by NOE experiments of 25. ... Cookies are used by this site. To decline or learn more, visit our Cookies page.