Journal of medicinal chemistry

Synthesis of selenium-75 labeled tertiary diamines: New brain imaging agents

H Kung, M Blau

Index: Kung, Hank; Blau, Monte Journal of Medicinal Chemistry, 1980 , vol. 23, # 10 p. 1127 - 1130

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Citation Number: 28

Abstract

Selenium-75 labeled tertiary diamines, bis [& (N, N-dimethy1amino) ethyll selenide (l), bis [p- (N, N-diisopropylamino) ethyl] selenide (2), bis (8-piperidinoethyl) selenide (3), and bis@ morpholinoethyl) selenide (4), were prepared by reducing [76Se] selenious acid with sodium borohydride and reacting the intermediate with the N, N-disubstituted aminoethyl chlorides. The effect of pH on lipid solubility (l-octanol/buffer distribution coefficient) was ...