Tetrahedron Letters

Phosphonium-mediated cyclization of N-(2-aminophenyl) thioureas: efficient synthesis of 2-aminobenzimidazoles

ZK Wan, EF Ousman, N Papaioannou, E Saiah

Index: Wan, Zhao-Kui; Ousman, Erena Farah; Papaioannou, Nikolaos; Saiah, Eddine Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4149 - 4152

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Citation Number: 12

Abstract

Abstract BOP efficiently promoted the phosphonium-mediated cyclization of thioureas, leading to a convenient synthesis of 2-aminobenzimidazoles. Compared to conventional methods, the reactions were complete at room temperature with times ranging from a few minutes to 1 h in near quantitative yields. This method is also applicable to the synthesis of more challenging structures such as 2-akylaminobenzimidazoles and 2-(N-acyl)- ...

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