Bridgehead intermediates in organic synthesis. A reproducible synthesis of adamantane-containing compounds

GA Kraus, TM Siclovan

Index: Kraus, George A.; Siclovan, Tiberiu M. Journal of Organic Chemistry, 1994 , vol. 59, # 4 p. 922 - 923

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Citation Number: 10

Abstract

Compounds containing the adamantane subunit have long been of interest to chemists due to the rigid structure and well-defined substitution chemistry of adamantane. l The discovery of the potent antiviral activity of amantadine (1-aminoadamantane) and rimantadine (a- methyl-l-adamantylmethylamine) has stimulated interest in the synthesis of adamantane- containing compounds. 2 The significant neuroprotective properties of the NMDA ...