Antibody-Based Therapeutics: Ultrasensitive NIR-SERRS Probes with Multiplexed Ratiometric Quantification for In Vivo Antibody Leads Validation (Adv. Healthcare Mater. 4/2018)

Homan Kang, Sinyoung Jeong, Ahla Jo, Hyejin Chang, Jin-Kyoung Yang, Cheolhwan Jeong, San Kyeong, Youn Woo Lee, Animesh Samanta, Kaustabh Kumar Maiti, Myeong Geun Cha, Taek-Keun Kim, Sukmook Lee, Bong-Hyun Jun, Young-Tae Chang, Junho Chung, Ho-Young Lee, Dae Hong Jeong, Yoon-Sik Lee

Index: 10.1002/adhm.201870019

Full Text: HTML

Abstract

In article number 1700870, Yoon-Sik Lee and co-workers demonstrate in vivo validation process of candidate antibodies against human colon cancer, using a ratiometric quantification method. The validation is performed on a single mouse and analyzed by multiplexed surface-enhanced resonance Raman scattering (SERRS) with ultrasensitive and near-infrared (NIR)-active SERRS nanoprobes (NIR-SERRS dots).