Tetrahedron letters

Highly convergent synthesis of a rebeccamycin analog with benzothioeno (2, 3-a) pyrrolo (3, 4-c) carbazole as the aglycone

J Wang, N Soundarajan, N Liu, K Zimmermann…

Index: Wang, Jianji; Soundarajan, Nachimuthu; Liu, Nian; Zimmermann, Kurt; Naidu, B. Narasimhulu Tetrahedron Letters, 2005 , vol. 46, # 6 p. 907 - 910

Full Text: HTML

Citation Number: 32

Abstract

A highly convergent, scalable synthesis of the rebeccamycin analog 2 was demonstrated in seven steps and 31% overall yield based on the N-protected building block dibromomaleimide 7. The practical synthesis of other two building blocks, 5, 6-difluoro-3- benzothiopheneboronic acid 6 and 5, 6-difluoroindole 8, is described.