Protein kinase C modulators. Indolactams. 1. Efficient and flexible routes for the preparation of (-)-indolactam V for use in the synthesis of analogs

J Quick, B Saha, PE Driedger

Index: Quick, James; Saha, Bijali; Driedger, Paul E. Tetrahedron Letters, 1994 , vol. 35, # 46 p. 8549 - 8552

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Citation Number: 28

Abstract

Abstract Three syntheses of the protein kinase C activator,(-)-indolactam V, are described and are compared for their potential utility in the preparation of ILV analogs. In one route the 4-amino functionality is introduced regiospecifically during the construction of the indole portion and enantiomeric control is achieved by the alkylation of the amine with a triflate derived from d-valine. One of the routes affords racemic ILV from which (-)-ILV is obtained ...