Tetrahedron

Synthesis of chiral isoxazolidin-5-ones and their applications to the synthesis of β-amino-alanines and β-(N-hydroxyamino)-alanines

JE Baldwin, RM Adlington, LC Mellor

Index: Baldwin, Jack E.; Adlington, Robert M.; Mellor, Lisa C. Tetrahedron, 1994 , vol. 50, # 17 p. 5049 - 5066

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Citation Number: 24

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Herein we report a high-yielding synthesis of isoxazolidin-5-ones and their use to synthesise both β-amino-alanines and β-(N-hydroxyamino)-alanines. ... A new route to isoxazolidin-5-ones (1) and (2) is described. Amino acids (3) and (4) were obtained via hydrogenation of (2) ...