Synthesis and anticonvulsant properties of some 2??aminoethanesulfonic acid (taurine) derivatives

L Andersen, LO Sundman, IB Lindèn…

Index: Andersen; Sundman; Linden; Kontro; Oja Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 1 p. 106 - 108

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Citation Number: 26

Abstract

Abstract A series of 2-acylaminoethanesulfonamides were synthesized by treating the corresponding sulfonyl chlorides with ammonia, a primary, or a secondary amine. A few compounds displayed marked anti-convulsant activity in mice when tested for their potency in the maximal electroshock seizure test. The piperidino, benzamido, phthalimido, and phenylsuccinylimido derivatives were active, whereas the succinylimido, saccharinylimido ...

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