… Catalyzed by a Ruthenium (II)/Trifluoroacetic Acid System: One??Pot Entry to Fully Substituted Furans from Readily Available Secondary Propargylic Alcohols and 1, 3 …

V Cadierno, J Gimeno, N Nebra

Index: Cadierno, Victorio; Gimeno, Jose; Nebra, Noel Advanced Synthesis and Catalysis, 2007 , vol. 349, # 3 p. 382 - 394

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Citation Number: 57

Abstract

Abstract A simple and highly efficient method for the preparation of tetrasubstituted furans starting from readily accessible propargylic alcohols and commercially available 1, 3- dicarbonyl compounds has been developed. The process, which proceeds in a one-pot manner, involves the initial propargylation of the 1, 3-dicarbonyl compound promoted by trifluoroacetic acid, and subsequent cycloisomerization of the resulting γ-ketoalkyne ...

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