Reduction of. DELTA. 2-isoxazolines. 3. Raney nickel catalyzed formation of. beta.-hydroxy ketones

DP Curran

Index: Curran Journal of the American Chemical Society, 1983 , vol. 105, # 18 p. 5826 - 5833

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Citation Number: 258

Abstract

Abstract: The importance of the@-hydroxy ketone moiety has led to the development of a wide variety of aldol type methodologies for its construction. A conceptually new approach to these" aldol adducts" is presented on the basis of [3+ 21 dipolar cycloaddition of in situ generated nitrile oxides and olefins followed by reduction of the resulting A2-isoxazolines. This approach provides a nice complement to the aldol type reaction. Optimum conditions ...