Design, synthesis and biological evaluation of biphenyl urea derivatives as novel VEGFR-2 inhibitors

C Wang, J Dong, Y Zhang, F Wang, H Gao, P Li…

Index: MedChemComm, , vol. 4, # 11 p. 1434 - 1438

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Citation Number: 16

Abstract

... 1). 4 Several small molecule VEGFR-2 inhibitors, such as sorafenib (BAY-43-9006, Bayer ... Sufficient space was available for the introduction of various substitutes to the terminal aniline. 11 Firstly, rearrangement of the arylcarbamoyl at the 2-position and the amide at the 2 ...