Cardiotonic agents. 1. 4, 5-Dihydro-6-[4-(1H-imidazol-1-yl) phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure
JA Bristol, I Sircar, WH Moos, DB Evans…
Index: Bristol, James A.; Sircar, Ila; Moos, Walter H.; Evans, Dale B.; Weishaar, Ronald E. Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1099 - 1101
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Citation Number: 176
Abstract
The pathophysiology of heart failure consists of (1) myocardial failure and (2) the consequent systemic response to the failing myocardium that ultimately leads to peripheral congestion and edema. lP2 The fundamental defect is an impairment of ventricular function that results in an inadequate output to meet the metabolic and circulatory demands of the body. Effective therapy of heart failure is directed to enhancement of the contractile state of ...
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