Journal of Materials Chemistry B 2018-04-11

Organic nanoparticles with ultrahigh quantum yield and aggregation-induced emission characteristics for cellular imaging and real-time two-photon lung vasculature imaging

Bin Liu, Maximilien Evrard, Xiaolei Cai, Guangxue Feng, Nikodem Tomczak, Lai Guan Ng, Jie Liu

Index: 10.1039/C8TB00386F

Full Text: HTML

Abstract

Fluorescent organic nanoparticles based on small molecules have emerged as an attractive class of fluorescent agents for bioimaging in recent years. Herein, we report an orange light-emitting BTPEBD based organic nanoparticles (BTPEBD NPs) with a large Stokes shift (> 135 nm), ultrahigh quantum yield (> 90% in water) and aggregation-induced emission characteristics. Single nanoparticle analysis studied by wide field microscopy imaging further proves that BTPEBD NPs exhibit high brightness and good photostability. Both in-vitro and in-vivo experiments reveal that BTPEBD NPs are promising fluorescent agents for cellular imaging and real-time two-photon lung vasculature imaging.

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