Synthesis and biological activity of L-5-deazafolic acid and L-deazaaminopterin: synthetic strategies to 5-deazapteridines

…, DC Palmer, TJ George, SR Fletcher…

Index: Taylor, Edward C.; Palmer, David C.; George, Thomas J.; Fletcher, Stephen R.; Tseng, Chi Ping; et al. Journal of Organic Chemistry, 1983 , vol. 48, # 25 p. 4852 - 4860

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Citation Number: 70

Abstract

azafolic acid (10) shows marginal activity against mouse L1210 leukemia, 14 the corresponding 5, 8, 10-trideazaaminopterin (1 1) exhibits confirmed inhibitory activity against mouse L1210 1e~ kemia. l~ Encouraged by these results, we have embarked upon a synthetic program aimed at the development of new synthetic routes to deazapteridines and the synthesis of the missing deaza derivatives of folic acid, aminopterin, and ...